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1.1 This procedure covers the determination of selected per- and polyfluoroalkyl substances (PFASs) in a water matrix using liquid chromatography (LC) and detection with tandem mass spectrometry (MS/MS). These analytes are qualitatively and quantitatively determined by this test method. This test method adheres to a technique known as selected reaction monitoring (SRM) or sometimes referred to as multiple reaction monitoring (MRM). This is not a drinking water method; performance of this test method has not been evaluated on drinking water matrices.

1.2 The method detection limit (MDL)2 and reporting range3 for the target analytes are listed in Table 1. The target concentration for the reporting limit for this test method was 10 ng/L for most of the target analytes at the time of development.

1.3 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.

1.4 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use.

1.5 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.

5.1 PFASs are widely used in various industrial and commercial products; they are persistent, bio-accumulative, and ubiquitous in the environment. PFASs have been reported to exhibit developmental toxicity, hepatotoxicity, immunotoxicity, and hormone disturbance. A draft Toxicological Profile for Perfluoroalkyls from the U.S. Department of Health and Human Services is available.6 PFASs have been detected in soils, sludges, surface, and drinking waters. Hence, there is a need for quick, easy, and robust method to determine these compounds at trace levels in water matrices for understanding of the sources and pathways of exposure.

5.2 This test method has been investigated for use with reagent, surface, sludge and wastewaters for selected PFASs. This test method has not been evaluated on drinking water matrices.