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ISO 21049:2004 specifies requirements and gives recommendations for sealing systems for centrifugal and rotary pumps used in the petroleum, natural gas and chemical industries. It is applicable mainly for hazardous, flammable and/or toxic services where a greater degree of reliability is required for the improvement of equipment availability and the reduction of both emissions to the atmosphere and life-cycle sealing costs. It covers seals for pump shaft diameters from 20 mm (0,75 in) to 110 mm (4,3 in).

ISO 21049:2004 is also applicable to seal spare parts and can be referred to for the upgrading of existing equipment. A classification system for the seal configurations covered by ISO 21049:2004 into categories, types, arrangements and orientations is provided.