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This document gives guidelines for the measurements of respirable crystalline silica in air using direct on-filter or indirect X-ray diffraction and infrared analysis methods, including quality aspects of the measurements. The scope of this document includes the following crystalline silica polymorphs: quartz and cristobalite. These guidelines are intended for use in conjunction with the following specific analytical methods under the jurisdiction of ISO TC 146 SC 2: ISO 16258-1, ISO 16258-2, and ISO 19087. When used with any of these documents, this guidance will help to ensure measurement procedures meet the uncertainty requirements stipulated in ISO 20581, to enable the results to be compared to occupational exposure limit values (OELV) in accordance with EN 689[40]. These guidelines are also relevant to the analysis of filters obtained from dustiness measurements in accordance with EN 15051[1] and EN 17289[35].