ASTM-E1073 › Historical Revision Information
Obtaining a Pharmacological Profile With Mice, Standard Testmethod For
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Scope
1.1 This test method is designed as a simple and inexpensive initial screening procedure for new compounds with unknown pharmacological properties, or for the comparative bioassay of new members of a chemical series with class reference standards. The test method, which is applicable to most pharmacologically active compounds including pesticides, will properly rank order both acute lethality and potency with a minimum expenditure of test material. It is intended as the first step in a multi-tiered development program.
1.2 This standard does not purport to address the safety problems associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.
Keywords
chemicals; ED50; LD50; manipulative tests; MED50; mice; nonmanipulative tests; pesticides; phamacology; toxicity; ICS Number Code 11.120.01 (Pharmaceutics in general)
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11.120.01 (Pharmaceutics in general)
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Document Number
ASTM-E1073-86
Revision Level
1986 EDITION
Status
Superseded
Modification Type
Revision
Publication Date
June 27, 1986
Document Type
Test Method
Page Count
14 pages
Committee Number
E35.26