ASTM-E1103 Standard Test Method for Determining Subchronic Dermal Toxicity (Withdrawn 2010)

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Standard Test Method for Determining Subchronic Dermal Toxicity (Withdrawn 2010)


1.1 This test method describes a procedure for the assessment and evaluation of the toxic characteristics of a test substance that is applied daily to the skin of experimental animals for 90 days.

1.2 This test method is not capable of determining effects that have a long latency period (for example, carcinogenicity) or are life shortening.

1.3 This test method is intended primarily to be used with rats, guinea pigs, or rabbits. Other species may be used with appropriate modifications.

1.4 This standard does not purport to address the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

Significance and Use

This test method provides information on health hazards likely to arise from repeated exposure to a pesticide or other chemical by the dermal route over a short time period. It may provide information needed to establish safety criteria for human exposure.

Signs of toxicity other than lethality can be observed.

This method can provide information on target organs and possible cumulative effects. It may aid in the selection of doses for chronic studies.


dermal toxicity; guinea pig; hazard; necropsy; rabbit; rat; skin; subchronic toxicity; ICS Number Code 11.100 (Laboratory medicine)

To find similar documents by ASTM Volume:

11.05 (Pesticides and Alternative Control Agents; Environmental Assessment; Hazardous Substances and Oil Spill Response)

11.06 (Biological Effects and Environmental Fate; Biotechnology)

To find similar documents by classification:

11.100 (Laboratory medicine)

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Document Number


Revision Level

1996 R04(E1) EDITION



Modification Type


Publication Date

Feb. 1, 2005

Document Type

Test Method

Page Count

4 pages

Committee Number