ASTM-E1103 › Standard Test Method for Determining Subchronic Dermal Toxicity (Withdrawn 2010)
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Scope
1.1 This test method describes a procedure for the assessment and evaluation of the toxic characteristics of a test substance that is applied daily to the skin of experimental animals for 90 days.
1.2 This test method is not capable of determining effects that have a long latency period (for example, carcinogenicity) or are life shortening.
1.3 This test method is intended primarily to be used with rats, guinea pigs, or rabbits. Other species may be used with appropriate modifications.
1.4 This standard does not purport to address the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.
Significance and Use
This test method provides information on health hazards likely to arise from repeated exposure to a pesticide or other chemical by the dermal route over a short time period. It may provide information needed to establish safety criteria for human exposure.
Signs of toxicity other than lethality can be observed.
This method can provide information on target organs and possible cumulative effects. It may aid in the selection of doses for chronic studies.
Keywords
dermal toxicity; guinea pig; hazard; necropsy; rabbit; rat; skin; subchronic toxicity; ICS Number Code 11.100 (Laboratory medicine)
To find similar documents by ASTM Volume:
11.06 (Biological Effects and Environmental Fate; Biotechnology)
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Document Number
ASTM-E1103-96(2004)e1
Revision Level
1996 R04(E1) EDITION
Status
Cancelled
Modification Type
Withdrawn
Publication Date
Feb. 1, 2005
Document Type
Test Method
Page Count
4 pages
Committee Number
E47.02