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This standard specifies procedures for the reduction of microbiological contamination of flight hardware using hydrogen peroxide vapour. The procedures specified in this standard cover: • Reduction of microbiological contamination on exposed surfaces. • Reduction of microbiological contamination in controlled ambient and vacuum environments. This standard also specifies requirements for the conditioning of the flight hardware, bioburden reduction cycle development, and equipment to be used for applying a bioburden reduction procedure. This standard may be tailored for the specific characteristics and constraints of a space project in conformance with ECSS-S-ST-00C.